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Dangal, Tamil dub video, watch and download film Dangal in high quality 720p, 1080p and Hd.Biological characterizations of the renin-angiotensin system in postnatal development in the murine kidney.
Previous studies indicated that the renin-angiotensin system (RAS) in the postnatal kidney is essential for normal kidney growth and development. We here provide biological evidence for the ontogenic development of RAS function and tissue concentration of its constituent peptides. Renal RAS was studied in mice from day 0 (the day of birth) to day 14 by monitoring the ontogenic development of: 1) the plasma concentration of renin (PRE) and prorenin (PREP), the enzymes whose products the RAS ultimately control, 2) tissue concentration of their catalytic enzymes, renin (Ren) and prorenin (PREN), and 3) tissue concentration of angiotensinogen (Aogen), the substrate to which cleaved by Ren and PREP eventually gives rise to angiotensin I, the biologically active peptide of the RAS. The immunochemical values of the parameters related to RAS were normalized with their respective body weight (BW) and kidney weight (KW), which were higher than in control mice, suggesting a direct correlation between RAS parameters and postnatal kidney growth. The ontogenic development of RAS parameters showed a different pattern from that of their correlated body and kidney parameters. In particular, PRE and PREP levels remained low until day 6 after birth and increased thereafter. A dramatic increase in Ren and PREN levels was found at around day 9. Aogen levels also increased rapidly during this period, reaching its maximum value at around day 10. Although the local RAS of renal tubules was demonstrated to be functional by measuring PRE and Ren levels in kidney sections, the RAS in different tubular parts, including the distal tubule, did not show a parallel ontogenic development. The results indicate that the ontogenic development of the RAS is more complicated than was earlier supposed and that different parts of

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